HCID 71683711, compound → 2,6-Difluoroaniline

HRID 1522911Notes

Reaction equation

HRID 1522911 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]([C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[N:14]([CH3:25])[N:13]=1)=[O:11].[F:26]C1C=CC(OC)=C(C2N(C)N=C(C(O)=O)C=2)C=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH2:9].[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[NH:9][C:10]([C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[C:21]([F:26])[CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[N:14]([CH3:25])[N:13]=1)=[O:11]

Participants

4

Reactant 2

HCID 71683711HCID 71683711, compoundHCID 90271579HCID 90271579, compound

Product 2

HCID 796472,6-DifluoroanilineYield 22%HCID 90271652HCID 90271652, compound

Procedure

The title compound of example 10 was prepared in analogy to the preparation of the title compound of example 1 through the reaction of 5-(5-fluoro-2-methoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (201 mg) with 2,6-difluoroaniline (105 mg) (22% yield).

Sources & evidence

ORD record
ord-2330bf09252944e59847b9241d6b6633
Source dataset
uspto-grants-2015_07
Patent number
US09078899B2

Reaction notes

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