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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15230Generated: October 25, 2026

1-Chloro-3-iodobenzene → 1-tert-Butoxycarbonyl-4-[2-(3-chloro-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

https://huagongshe.com/reaction/15230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-3-iodobenzeneHCID 12269—
Reactant4-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl esterHCID 68682113—
Product1-tert-Butoxycarbonyl-4-[2-(3-chloro-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-olHCID 68684587—

Reaction Steps

Prepared from 4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester and 1-chloro-3-iodo-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732463B2
Source datasetuspto-grants-2010_06
ORD IDord-6a624a10c1a14545a7efd7318c2e227e
Source noteuspto-grants-2010_06