Phenethyl bromide → 5-Methyl-1-phenethylindoline-2,3-dione

HRID 1523022Notes

Reaction equation

C(N1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=O)[C:5]1=O)CC.[CH3:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2=[O:26].C1C=CC(CCBr)=CC=1>>[CH3:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[N:21]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:20](=[O:25])[C:19]2=[O:26]

Participants

Reactant 3

HCID 7666Phenethyl bromide

HCID 118405-Methylisatin

HCID 16450901-propyl-1H-indole-2,3-dione

Product 1

HCID 31579095-Methyl-1-phenethylindoline-2,3-dione

Procedure

Was prepared in an analogous manner to 1-propylindoline-2,3-dione using 5-methyl isatin (purchased from Fisher Scientific) and 2-phenethyl bromide (purchased from Fisher Scientific).

Sources & evidence

ORD record: ord-a50cfeb84a0140fca39138d8366db02a
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09079853B2

Reaction notes

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