1-Bromo-2-methylpropane → 1-Isobutyl-5-methylindoline-2,3-dione

HRID 1523026Notes

Reaction equation

C(N1[C:12]2[C:7](=[CH:8]C=CC=2)[C:6](=O)C1=O)CC.[CH3:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2=[O:26].BrCC(C)C>>[CH2:6]([N:21]1[C:22]2[C:18](=[CH:17][C:16]([CH3:15])=[CH:24][CH:23]=2)[C:19](=[O:26])[C:20]1=[O:25])[CH:7]([CH3:12])[CH3:8]

Participants

Reactant 3

HCID 65551-Bromo-2-methylpropane

HCID 118405-Methylisatin

HCID 16450901-propyl-1H-indole-2,3-dione

Product 1

HCID 47302401-Isobutyl-5-methylindoline-2,3-dione

Procedure

Was made in an analogous fashion to 1-propylindoline-2,3-dione using 5-methyl isatin (purchased from Fisher Scientific) and 1-bromo-2-methyl propane (purchased from Fisher Scientific). 1H NMR δ 7.42 (m, 2H), 6.79 (d, 1H), 3.52 (d, 2H), 2.33 (s, 3H), 2.08 (m, 1H), 0.99 (d, 6H).

Sources & evidence

ORD record: ord-fc67e7640d1147729481e2008a3a4fb6
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09079853B2

Reaction notes

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