2-Oxo-1-propylindolin-3-yl benzoate → 5-Chloro-1-(3-morpholinopropyl)-2-oxoindolin-3-yl benzoate

HRID 1523044Notes

Reaction equation

HRID 1523044 reaction equation
[C:1](OC1C2C(=CC=CC=2)N(CCC)C1=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:23][C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[N:29]([CH2:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1)[C:28](=[O:42])[C:27]2=[O:43]>>[C:1]([O:43][CH:27]1[C:26]2[C:30](=[CH:31][CH:32]=[C:24]([Cl:23])[CH:25]=2)[N:29]([CH2:33][CH2:34][CH2:35][N:36]2[CH2:37][CH2:38][O:39][CH2:40][CH2:41]2)[C:28]1=[O:42])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 904164392-Oxo-1-propylindolin-3-yl benzoateHCID 904174465-Chloro-1-(3-morpholinopropyl)indoline-2,3-dione

Product 1

HCID 904164975-Chloro-1-(3-morpholinopropyl)-2-oxoindolin-3-yl benzoate

Procedure

This compound was prepared in a similar way to 2-oxo-1-propylindolin-3-yl benzoate from 5-chloro-1-(3-morpholinopropyl)indoline-2,3-dione. 1H-NMR δ 8.07 (dd, 2H), 7.63 (dd, 1H), 7.53 (dd, 2H), 7.42 (s, 1H), 7.33 (dd, 1H), 7.6.92 (d, 1H), 6.09 (s, 1H), 3.84 (m, 2H), 3.76 (m, 4H), 2.50 (m, 6H), 1.97 (m, 2H).

Sources & evidence

ORD record
ord-0e49912cbd5546259b23479964ec1efc
Source dataset
uspto-grants-2015_07
Patent number
US09079853B2

Reaction notes

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