HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-1-(2-phenylethyl)-1H-indole-2,3-dione → 5-Chloro-3-hydroxy-3-((3-methoxypyridin-2-yl)methyl)-1-phenethylindolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-1-(2-phenylethyl)-1H-indole-2,3-dione | HCID 2930041 | — |
| Reactant | 3-Methoxy-2-methylpyridine | HCID 3015270 | — |
| Reactant | 3-((3-Bromopyridin-2-yl)methyl)-3-hydroxy-1-isopentyl-5-methylindolin-2-one | HCID 90418661 | — |
| Product | 5-Chloro-3-hydroxy-3-((3-methoxypyridin-2-yl)methyl)-1-phenethylindolin-2-one | HCID 86300398 | — |
Reaction Steps
This compound was prepared in an analogous manner to 3-((3-bromopyridin-2-yl)methyl)-3-hydroxy-1-isopentyl-5-methylindolin-2-one using 5-chloro-1-phenethylindoline-2,3-dione and 3-methoxy-2-methylpyridine. 1H-NMR δ 8.21 (dd, 1H), 7.33-7.17 (m, 8H), 6.95 (d, 1H), 6.62 (d, 1H), 5.5 (bs, OH), 3.98 (m, 1H), 3.86 (m, 1H), 3.78 (s, 3H), 3.37 (d, 1H), 3.09 (d, 1H), 2.96 (t, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-9c9983739c894e7caaf4cccdf1b342ec |
| Source note | uspto-grants-2015_07 |