HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyridine → 5-Chloro-1-ethyl-3-hydroxy-3-(pyridin-2-ylmethyl)indolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyridine | HCID 7975 | — |
| Reactant | 5-Chloro-1-ethylindoline-2,3-dione | HCID 2989602 | — |
| Reactant | 3-((3-Bromopyridin-2-yl)methyl)-3-hydroxy-1-isopentyl-5-methylindolin-2-one | HCID 90418661 | — |
| Product | 5-Chloro-1-ethyl-3-hydroxy-3-(pyridin-2-ylmethyl)indolin-2-one | HCID 86300395 | — |
Reaction Steps
This compound was prepared in an analogous manner to 3-((3-bromopyridin-2-yl)methyl)-3-hydroxy-1-isopentyl-5-methylindolin-2-one using 5-chloro-1-ethylindoline-2,3-dione and 2-methylpyridine (purchased from Fisher Scientific). 1H-NMR δ 8.60 (d, 1H), 7.65 (dd, 1H), 7.27 (m, 3H), 7.09 (d, 1H), 6.75 (m, 2H), 3.72 (m, 2H), 3.35 (d, 1H), 3.09 (d, 1H), 1.21 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-beec32e7d822436e9fd4c51e707bcfe4 |
| Source note | uspto-grants-2015_07 |