1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one → 5-Chloro-3-hydroxy-1-isobutyl-3-(2-(6-methoxypyridin-2-yl)-2-oxoethyl)indolin-2-one

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Reaction Steps

This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one from 5-chloro-1-isobutylindoline-2,3-dione and 1-(6-methoxypyridin-2-yl)ethanone (purchased from Fisher Scientific). 1H-NMR δ 7.75 (m, 1H), 7.67 (d, 1H), 7.35 (d, 1H), 7.29 (d, 1H), 7.00 (dd, 1H), 6.79 (d, 1H) 5.40 (bs, OH), 4.00 (m, 4H), 3.57-3.43 (m, 3H), 2.14 (m, 1H), 0.97 (dd, 6H). calculated mass for C20H21N2O4, 388.12, observed, 389.1 (M+1).

Provenance & Evidence