HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → 5-Chloro-1-ethyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | 1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one | HCID 2944160 | — |
| Reactant | 5-Chloro-1-ethylindoline-2,3-dione | HCID 2989602 | — |
| Product | 5-Chloro-1-ethyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one | HCID 86300244 | — |
Reaction Steps
This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 5-chloro-1-ethylindoline-2,3-dione and 2-acetyl pyridine (purchased from Fisher Scientific). 1H-NMR δ 8.70 (ddd, 1H), 8.11 (dd, 1H), 7.93 (ddd, 1H), 7.57 (ddd, 1H), 7.31-7.27 (m, 2H), 6.79 (d, 1H), 5.5 (bs, OH), 3.77 (d, 1H), 3.74 (m, 2H), 3.53 (d, 1H), 1.27 (t, 3H). calculated mass for C17H15ClN2O3, 330.08, observed, 331.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-266eec5a69eb417ba7ce447bad78e66d |
| Source note | uspto-grants-2015_07 |