HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Acetylindole → 3-(2-(1H-indol-3-yl)-2-oxoethyl)-3-hydroxy-1-isobutylindolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Acetylindole | HCID 12802 | — |
| Reactant | 1-(2-methylpropyl)-2,3-dihydro-1H-indole-2,3-dione | HCID 2387233 | — |
| Reactant | 1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one | HCID 2944160 | — |
| Product | 3-(2-(1H-indol-3-yl)-2-oxoethyl)-3-hydroxy-1-isobutylindolin-2-one | HCID 90417547 | — |
Reaction Steps
This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 1-isobutylindoline-2,3-dione and commercially available 1-(1H-indol-3-yl)ethanone (purchased from Fisher Scientific). 1H-NMR δ 8.87 (bs, NH), 8.38 (m, 1H), 7.72 (d, 3.1 Hz, 1H), 7.49 (dd, 1H), 7.47 (m, 1H) 7.30 (m, 3H), 7.01 (dd, 1H), 6.86 (d, 7.8, 1H), 3.51 (m, 3H), 3.24 (d, 1H), 2.16 (m, 1H) 0.98 (dd, 6H). Calculated mass for C22H22N2O3, 362.16. Observed 385.3 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-6ffa21d4d33d49d888dd341da70444c3 |
| Source note | uspto-grants-2015_07 |