HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → 5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-propylindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | 1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one | HCID 2944160 | — |
| Reactant | 5-Chloro-1-propylindoline-2,3-dione | HCID 2988281 | — |
| Product | 5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-propylindol-2-one | HCID 4909215 | — |
Reaction Steps
This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 5-chloro-1-propylindoline-2,3-dione and 2-acetyl pyridine (purchased from Fisher Scientific). 1H-NMR δ 8.70 (d, 1H), 8.10 (d, 1H), 7.92 (t, 1H), 7.56 (dd, 1H), 7.28 (m, 2H), 6.79 (d, 1H), 3.63 (m, 5H), 1.70 (m, 2H), 0.96 (t, 3H). Calculated mass for C18H17ClN2O3, 344.09. Observed 345.0 (M+1), 367.1 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-29668913828145f8a9d16d42296ec4fe |
| Source note | uspto-grants-2015_07 |