1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one → 3-Hydroxy-1-isobutyl-3-(2-(6-methoxypyridin-2-yl)-2-oxoethyl)-5-methylindolin-2-one

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Reaction Steps

This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 1-isobutyl-5-methylindoline-2,3-dione and commercially available 1-(6-methoxypyridin-2-yl)ethanone (purchased from Fisher Scientific). 1H-NMR δ 7.70 (m, 2H), 7.19 (d, 1H), 7.10 (d, 1H), 6.97 (dd, 1H), 6.75 (d, 1H), 5.39 (s, OH), 4.02-3.98 (m, 4H), 3.56-3.42 (m, 3H), 2.30 (s, 3H), 2.16 (m, 1H), 0.97 (dd, 6H). calculated mass for C21H24N2O4, 368.17, observed, 391.1 (M+Na).

Provenance & Evidence