HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → 5-Chloro-3-hydroxy-1-isobutyl-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | 1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one | HCID 2944160 | — |
| Reactant | 5-Chloro-1-isobutylindoline-2,3-dione | HCID 4736865 | — |
| Product | 5-Chloro-3-hydroxy-1-isobutyl-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one | HCID 86300543 | — |
Reaction Steps
This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 5-chloro-1-isobutylindoline-2,3-dione and commercially available 2-acetyl pyridine (purchased from Fisher Scientific). 1H-NMR δ 8.71 (ddd, 1H), 8.13 (dd, 1H), 7.93 (dd, 1H), 7.56 (ddd, 1H), 7.31 (d, 1H), 7.28-7.26 (m, 2H), 6.78 (d, 1H), 3.74 (dd, 1H), 3.56-3.40 (m, 3H), 2.13 (m, 1H), 0.96 (d, 6H). calculated mass for C19H19ClN2O3, 358.11, observed, 359.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079853B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-e177841f1b604f1f826b9ebf77c7c7c6 |
| Source note | uspto-grants-2015_07 |