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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1523082Generated: October 30, 2026

1-Ethyl-3-hydroxy-5-methyl-3-(3,4,5-trimethoxybenzyl)indolin-2-one → 3-Hydroxy-1-isobutyl-5-methyl-3-(3,4,5-trimethoxybenzyl)indolin-2-one

https://huagongshe.com/reaction/1523082

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-hydroxy-5-methyl-3-(3,4,5-trimethoxybenzyl)indolin-2-oneHCID 86300542—
Reactant1-Isobutyl-5-methyl-2-oxoindolin-3-yl benzoateHCID 90416087—
Product3-Hydroxy-1-isobutyl-5-methyl-3-(3,4,5-trimethoxybenzyl)indolin-2-oneHCID 86301125—

Reaction Steps

This compound was made in an analogous fashion to 1-ethyl-3-hydroxy-5-methyl-3-(3,4,5-trimethoxybenzyl)indolin-2-one using 5-methyl-1-isobutyl-2-oxoindolin-3-yl benzoate. 1H-NMR δ 7.22 (s, 1H), 7.08 (d, 1H), 6.58 (d, 2H), 6.1 (s, 2H), 3.74 (s, 3H), 3.63 (s, 6H), 3.48 (m, 1H), 3.29 (d, 1H), 3.11 (m, 1H), 3.06 (bs, OH), 2.35 (s, 3H), 1.85 (m, 1H), 0.70 (dd, 6H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09079853B2
Source datasetuspto-grants-2015_07
ORD IDord-f294a3115a704ab8ad10b8c400aa1fce
Source noteuspto-grants-2015_07