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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1523084Generated: October 30, 2026

3-Methoxybenzyl chloride → 5-Chloro-1-ethyl-3-(3-methoxybenzyl)-2-oxoindolin-3-yl benzoate

https://huagongshe.com/reaction/1523084

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methoxybenzyl chlorideHCID 69994—
Reactant1-Ethyl-5-methyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoateHCID 86300681—
Reactant5-Chloro-1-ethyl-2-oxoindolin-3-yl benzoateHCID 90416168—
Product5-Chloro-1-ethyl-3-(3-methoxybenzyl)-2-oxoindolin-3-yl benzoateHCID 86301274—

Reaction Steps

This compound was made in an analogous fashion to 1-ethyl-5-methyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl benzoate using 5-chloro-1-ethyl-2-oxoindolin-3-yl benzoate and 3-methoxy benzyl chloride (purchased from Fisher Scientific). 1H NMR δ 8.06 (d, 2H), 7.61 (t, 1H), 7.46 (t, 2H), 7.25 (dd, 1H), 7.09 (t, 1H), 7.02 (d, 1H), 6.76 (dd, 1H), 6.64 (m, 2H), 6.52 (s, 1H), 3.72 (m, 4H), 3.57 (m, 2H), 3.27 (d, 1H), 1.04 (t, 3H). Calculated mass for C25H22NClO4, 435.12. Observed 458.1 (M+Na).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09079853B2
Source datasetuspto-grants-2015_07
ORD IDord-6130dcb7a9bf4bd88a0ef16ab5da0951
Source noteuspto-grants-2015_07