3-((1H-indol-3-yl)methyl)-5-chloro-2-oxo-1-propylindolin-3-yl benzoate → 3-((1H-indol-3-yl)methyl)-1-butyl-2-oxoindolin-3-yl benzoate

HRID 1523100Notes

Reaction equation

HRID 1523100 reaction equation
[C:1]([O:9][C:10]1([CH2:24][C:25]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:27][CH:26]=2)[C:18]2[C:13](=[CH:14][CH:15]=[C:16](Cl)[CH:17]=2)[N:12]([CH2:20][CH2:21][CH3:22])[C:11]1=[O:23])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:34](OC1C2C(=CC=CC=2)N(CCCC)C1=O)(=O)C1C=CC=CC=1.C(OCC1C2C(=CC=CC=2)N(C(=O)C2C=CC=CC=2)C=1)(=O)C1C=CC=CC=1>>[C:1]([O:9][C:10]1([CH2:24][C:25]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:27][CH:26]=2)[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH2:20][CH2:21][CH2:22][CH3:34])[C:11]1=[O:23])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 863014383-((1H-indol-3-yl)methyl)-5-chloro-2-oxo-1-propylindolin-3-yl benzoateHCID 90411032HCID 90411032, compoundHCID 904158001-Butyl-2-oxoindolin-3-yl benzoate

Product 1

HCID 863012783-((1H-indol-3-yl)methyl)-1-butyl-2-oxoindolin-3-yl benzoate

Procedure

This compound was made in an analogous method as 3-((1H-indol-3-yl)methyl)-5-chloro-2-oxo-1-propylindolin-3-yl benzoate) using 1-butyl-2-oxoindolin-3-yl benzoate and (1-benzoyl-1H-indol-3-yl)methyl benzoate. 1H-NMR δ 8.03 (d, 2H), 7.97 (bs, NH), 7.54 (t, 1H), 7.48 (d, 1H), 7.42 (m, 2H), 7.28 (d, 1H), 7.24 (dd, 1H), 7.15 (m, 2H), 7.05 (dd, 1H), 6.94 (dd, 1H), 6.70 (m, 2H), 3.75 (d, 1H), 3.68 (m, 1H), 3.52 (d, 1H), 3.41 (m, 1H), 1.28-1.09 (m, 4H), 0.81 (t, 3H).

Sources & evidence

ORD record
ord-ed20bbe8402b472abea2cc35c12bd245
Source dataset
uspto-grants-2015_07
Patent number
US09079853B2

Reaction notes

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