Acetonitrile → 3-(3-(3-Benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile

HRID 1523185노트

반응식

HRID 1523185 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21](#[N:23])[CH3:22]>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:16]([OH:17])[CH2:22][C:21]#[N:23])[CH:18]=[CH:19][CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 6342AcetonitrileHCID 866376223-(3-(Benzyloxy)propoxy)benzaldehyde

생성물 1

HCID 673169703-(3-(3-Benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile

실험 절차

Addition of acetonitrile to 3-(3-benzyloxy-propoxy)-benzaldehyde gave 3-(3-(3-benzyloxy-propoxy)-phenyl)-3-hydroxy-propionitrile as yellow oil. Yield (0.94 g, 54%): 1H NMR (400 MHz, CDCl3) δ 7.23-7.38 (m, 6H), 6.90-6.96 (m, 2H), 6.81-6.86 (m, 1H), 5.00 (m, 1H), 4.53 (s, 2H), 4.10 (t, J=6.2 Hz, 2H), 3.67 (t, J=6.0, 2H), 2.75 (t, J=6.4, 2H), 2.04-2.13 (m, 2H).

출처 및 근거

ORD 기록
ord-ca733fea755140b9b29a751ef85c66c5
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079825B2

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