1,4-Dioxane hydrochloride → HCID 59627240, compound

HRID 1523234Notes

Reaction equation

HRID 1523234 reaction equation
CC(C)([S@@]([NH:6][C@:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH3:19])[CH2:8][C:9]([NH:11][C:12]1[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=1)=[O:10])=O)C.Cl.O1CCOCC1>CO>[NH2:6][C@:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH3:19])[CH2:8][C:9]([NH:11][C:12]1[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=1)=[O:10]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68730771HCID 68730771, compound

Product 1

HCID 59627240HCID 59627240, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (R)-3-((S)-1,1-dimethylethylsulfinamido)-3-phenyl-N-m-tolylbutanamide (300 mg, 0.81 mmol) in MeOH (5 mL) was added 4M HCl/dioxane (3 mL, 12 mmol). The solution was stirred for 1 h and concentrated to give (R)-3-amino-3-phenyl-N-m-tolylbutanamide (218 mg, 90%) without purification.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-68e9ada487f246349a769c960b9d337a
Source dataset
uspto-grants-2015_07
Patent number
US09079861B2

Reaction notes

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