Hydrochloric Acid → HCID 59627206, compound

Participants

Reaction Steps

A 50-mL round-bottomed flask was charged with methyl (S)-1-(4-bromophenyl)ethyl((S)-3-((S)-1,1-dimethylethylsulfinamido)-3-(4-fluorophenyl)hex-5-enyl)carbamate (96 mg, 0.17 mmol) and 4 M HCl in dioxane (10 mL, 40 mmol) while cooling in an ice-water bath. The reaction mixture was concentrated to give crude methyl (S)-3-amino-3-(4-fluorophenyl)hex-5-enyl((S)-1-(4-bromophenyl)ethyl)carbamate, which was used to the next step without purification.

Provenance & Evidence