4-Fluorophenylboronic acid → HCID 59627215, compound

HRID 1523248Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.[CH2:11]([C@@:14]1([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH2:19][CH2:18][N:17]([C@H:20]([C:22]2[CH:27]=[CH:26][C:25](Br)=[CH:24][CH:23]=2)[CH3:21])[C:16](=[O:29])[NH:15]1)[CH:12]=[CH2:13]>>[CH2:11]([C@@:14]1([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH2:19][CH2:18][N:17]([C@H:20]([C:22]2[CH:27]=[CH:26][C:25]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:24][CH:23]=2)[CH3:21])[C:16](=[O:29])[NH:15]1)[CH:12]=[CH2:13]

Participants

Reactant 2

HCID 2856454-Fluorophenylboronic acid

HCID 59627199HCID 59627199, compound

Product 1

HCID 59627215HCID 59627215, compound

Procedure

(S)-4-allyl-1-((S)-1-(4′-fluorobiphenyl-4-yl)ethyl)-4-(4-fluorophenyl)tetrahydropyrimidin-2(1H)-one was prepared following a procedure analogous to that described in Example 4 using 4-fluorophenylboronic acid and (S)-4-allyl-1-((S)-1-(4-bromophenyl)ethyl)-4-(4-fluorophenyl)tetrahydropyrimidin-2(1H)-one.

Sources & evidence

ORD record: ord-31e91beaec2c496ba65312db52c69ff5
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09079861B2

Reaction notes

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