HCID 59627199, compound → HCID 59627205, compound

Participants

Reaction Steps

(S)-1-((S)-1-(4-bromophenyl)ethyl)-4-(4-fluorophenyl)-4-(3-hydroxypropyl)-3-methyltetrahydropyrimidin-2(1H)-one was prepared from (S)-4-allyl-1-((S)-1-(4-bromophenyl)ethyl)-4-(4-fluorophenyl)-3-methyltetrahydropyrimidin-2(1H)-one following a procedure analogous to that described in Example 10. (S)-4-allyl-1-((S)-1-(4-bromophenyl)ethyl)-4-(4-fluorophenyl)-3-methyltetrahydropyrimidin-2(1H)-one was prepared from (S)-4-allyl-1-((S)-1-(4-bromophenyl)ethyl)-4-(4-fluorophenyl)tetrahydropyrimidin-2(1H)-one following a procedure analogous to that described in Example 3. LC-MS Method 1 tR=1.383 min, m/z=449.1; 1H NMR (CDCl3) δ=1.20 (m, 1H), 1.35 (m, 3H), 1.60 (m, 2H), 1.71 (m, 1H), 1.98 (m, 2H), 2.12 (m, 1H), 2.49 (m, 1H), 2.64 (m, 1H), 2.83 (m, 3H), 3.70 (m, 2H), 5.85 (m, 1H), 7.01 (m, 2H), 7.13 (m, 4H), 7.39 (m, 2H).

Provenance & Evidence