Potassium Carbonate → HCID 59627242, compound

Participants

Reaction Steps

To a solution of (S)-1-(4-bromophenyl)ethanamine (100 g, 0.502 mol) and K2CO3 (138.8 g, 0.10 mol) in acetonitrile (1000 mL) was added a solution of 3-chloro-1-phenyl-propan-1-one (84.4 g, 0.502 mol) in acetonitrile (100 mL). The reaction mixture was stirred overnight. The solid was filtered, and the filtrate was concentrated to give crude (S)-3-(1-(4-bromo-phenyl)ethylamino)-1-phenylpropan-1-one (110 g, 66.2%), which was used in the next step without further purification.

Provenance & Evidence