Triethylamine → HCID 59627202, compound

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Reaction Steps

To a solution of N1-[1-(4-Bromo-phenyl)-ethyl]-5-methyl-3-phenyl-hex-5-ene-1,3-diamine (2.97 g, 0.007 mol) and Et3N (3.53 g, 0.035 mol) was added triphosgene (0.58 g, 0.002 mol) at 0° C. The resulting mixture was stirred for 3 h. The mixture was washed with water, the organic layer was separated, and concentrated to give the crude (R)-1-((S)-1-(4-bromophenyl)ethyl)-4-(2-methylallyl)-4-phenyltetrahydropyrimidin-2(1H)-one (1.1 g, 40%). which was purified by column chromatography. 1H NMR (CDCl3): δ=1.24 (s, 3H), 1.38 (m, 1H), 1.43 (d, 3H), 1.56 (m, 1H), 1.88 (m, 1H), 2.09 (m, 1H), 2.12 (m, 1H), 2.44 (m, 1H), 2.64 (m, 2H) 4.72 (s, 1H), 4.83 (s, 1H), 5.21 (s, 1H), 5.74 (m, 1H), 6.90 (m, 2H), 6.92-7.14 (m, 2H), 7.18-7.38 (m, 5H).

Provenance & Evidence