m-Chloroperbenzoic acid → HCID 59627214, compound

Participants

Reaction Steps

To a solution of (R)-1-((5)-1-(4-bromophenyl)ethyl)-4-(2-methylallyl)-4-phenyltetrahydropyrimidin-2(1H)-one (0.6 g, 1.45 mmol) in CH2Cl2 (15 mL) was added to m-CPBA (0.59 g, 2.9 mmol). The resulting solution was stirred overnight. The mixture was diluted with methyl tert-butyl ether (100 mL) and washed with 30 wt % aq sodium thiosulfate (3×50 mL) and saturated aqueous sodium bicarbonate (3×50 mL). The organic layer was dried over Na2SO4, filtered and then concentrated to afford (4S)-1-((S)-1-(4-bromophenyl)ethyl)-4-((2-methyloxiran-2-yl)methyl)-4-phenyltetrahydropyrimidin-2(1H)-one (0.61 g, Yield: 98%).

Provenance & Evidence