2-Bromo-1-(4-(difluoromethoxy)phenyl)ethan-1-one → 2-[4-(Difluoromethoxy)phenyl]-2-oxoethyl (3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)acetate

HRID 1523286Notes

Reaction equation

HRID 1523286 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]1([CH2:16][C:17]([OH:19])=[O:18])[CH2:15][O:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH:31]([F:33])[F:32])=[CH:26][CH:25]=1)=[O:23]>>[CH2:1]([O:8][C:9]([NH:11][C:12]1([CH2:16][C:17]([O:19][CH2:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH:31]([F:32])[F:33])=[CH:28][CH:29]=2)=[O:23])=[O:18])[CH2:13][O:14][CH2:15]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7034962-Bromo-1-(4-(difluoromethoxy)phenyl)ethan-1-oneHCID 895254372-(3-{[(Benzyloxy)carbonyl]amino}oxetan-3-yl)acetic acid

Product 1

HCID 1238337402-[4-(Difluoromethoxy)phenyl]-2-oxoethyl (3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)acetate

Procedure

Prepared by Method E using (3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)acetic acid (Preparation 25, 0.3 g, 1.13 mmol) and 2-bromo-1-[4-(difluoromethoxy)phenyl]ethanone (0.315 g, 1.19 mmol) to afford the title compound.

Workup

  1. customPrepared by Method E

Sources & evidence

ORD record
ord-10f24c3c5b8b47d499d91fb7db7b3b98
Source dataset
uspto-grants-2015_07
Patent number
US09079878B2

Reaction notes

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