2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → HCID 89525379, compound

HRID 1523287Notes

Reaction equation

HRID 1523287 reaction equation
[C:1]([S:5]([NH:7][C:8]1([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH2:11][O:10][CH2:9]1)=[O:6])([CH3:4])([CH3:3])[CH3:2].Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=1)=[O:20]>>[C:1]([S:5]([NH:7][C:8]1([CH:12]([CH3:16])[C:13]([O:15][CH2:18][C:19](=[O:20])[C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]([F:29])([F:30])[F:31])=[CH:23][CH:22]=2)=[O:14])[CH2:9][O:10][CH2:11]1)=[O:6])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27786912-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-oneHCID 89525751HCID 89525751, compound

Product 1

HCID 89525379HCID 89525379, compoundYield 66.1%

Procedure

Prepared by Method E using 2-{3-[(tert-butylsulfinyl)amino]oxetan-3-yl}propanoic acid (Preparation 26, 1.18 g, 4.733 mmol) and 2-bromo-1-[4-(trifluoromethoxy)phenyl]-ethanone (1.47 g, 5.21 mmol). The residue was purified by silica gel column chromatography to afford the title compound (1.413 g, 66% yield).

Workup

  1. customPrepared by Method E
  2. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-518bfbd1606a4395ba7e8b734ab1ab81
Source dataset
uspto-grants-2015_07
Patent number
US09079878B2

Reaction notes

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