HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1523290Generated: November 3, 2026
2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → HCID 123876920, compound
https://huagongshe.com/reaction/1523290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one | HCID 2778691 | — |
| Reactant | 4-[(tert-Butoxycarbonyl)amino]-4-(carboxymethyl)tetrahydro-2H-pyran, 4-Amino-4-(carboxymethyl)tetrahydro-2H-pyran, N-BOC protected | HCID 17040196 | — |
| Product | HCID 123876920 | HCID 123876920 | 105.1% |
Reaction Steps
Prepared by Method F using {4-[(tert-butoxycarbonyl)amino]tetrahydro-2H-pyran-4-yl}acetic acid (0.259 g, 1.00 mmol) and 2-bromo-1-[4-(trifluoromethoxy)phenyl]-ethanone (0.283 g, 1.00 mmol). The reaction was stirred at 50° C. for 50 minutes. The residue was isolated as a crude oil that crystallised to afford the title compound as a solid (0.485 g, 105% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09079878B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-aec207343c1f4bdcb52094cd487f90a2 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
