HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-methoxyaniline → 1-tert-Butoxycarbonyl-4-[2-(4-methoxy-2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-methoxyaniline | HCID 7610 | — |
| Reactant | 1-Iodo-4-methoxy-2-methylbenzene | HCID 13140160 | — |
| Reactant | 4-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester | HCID 68682113 | — |
| Product | 1-tert-Butoxycarbonyl-4-[2-(4-methoxy-2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol | HCID 68685969 | — |
Reaction Steps
Prepared from 4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester and 1-iodo-4-methoxy-2-methyl-benzene (prepared from 4-methoxy-2-methyl-phenylamine by diazotization according to the general procedure by Tunney and Stille J. Org. Chem. 1987, 52, 748-753).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732463B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0c2e9039a9924478966b3792f940004f |
| Source note | uspto-grants-2010_06 |