HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 25139344, compound → HCID 23151271, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 25139344 | HCID 25139344 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 23151271 | HCID 23151271 | 95.7% |
Reaction Steps
Hydrogen gas was bubbled through a solution of 1-Cyclobutyl-4-(4-nitrophenoxy)piperidine (94.9 g, 0.344 moles, obtained in above step) over 10% Pd/C (95 g) in methanol (2 L) at room temperature, for 5 hours. The mixture was filtered through a pad of celite, and the filtrate was concentrated under vacuum to obtain the title compound 81 g (Yield: 95.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079888B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-263f63ceb69d4eda97f288f9178832e6 |
| Source note | uspto-grants-2015_07 |