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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15234Generated: October 25, 2026

2-Iodotoluene → 1-tert-Butoxycarbonyl-4-[2-(2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

https://huagongshe.com/reaction/15234

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-IodotolueneHCID 5128—
Reactant4-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl esterHCID 68682113—
Product1-tert-Butoxycarbonyl-4-[2-(2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-olHCID 68684270—

Reaction Steps

Prepared from 4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester and 1-iodo-2-methyl-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732463B2
Source datasetuspto-grants-2010_06
ORD IDord-6485b40ff1d646ba9c4f377cd9a61c1c
Source noteuspto-grants-2010_06