Potassium Carbonate → HCID 60196778, compound

Participants

Reaction Steps

A mixture of 4-(1-Cyclobutyl piperidin-4-yloxy)aniline (0.5 g, 0.002 moles), 2-Chloro-1-(morpholin-4-yl)ethanone (0.5 g, 0.003) and potassium carbonate (0.56 g, 0.004 moles) in dimethylformamide (25 ml) was stirred at reflux temperature. After completion of reaction, the mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate (250 mL) and water (250 mL). The combined organic layers were washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure. The crude compound was purified by flash chromatography (chloroform: triethylamine, 9.5:0.5) to obtain the title compound 0.3 g (Yield: 40%).

Provenance & Evidence