反应详情

温度

0 °C

To a solution of 3-(3-nitropyridin-4-yl)cyclohex-2-enone (1.0 equiv.) was added EtOH (0.2 M) and CeCl3-7H2O (1.3 equiv.). The reaction was cooled to 0° C., then NaBH4 (1.3 equiv.) was added in portions. Stirred for 2 h at 0° C., then quenched by adding water, concentrated to remove the EtOH, added EtOAc, extracted the organics, dried with brine, then Na2SO4, and concentrated to yield 3-(3-nitropyridin-4-yl)cyclohex-2-enol (99%). LC/MS=221.1 (M+H), LC=2.235 min.

1. customquenched
2. additionby adding water
3. concentrationconcentrated
4. customto remove the EtOH
5. additionadded EtOAc
6. extractionextracted the organics,
7. dry with materialdried with brine
8. concentrationNa2SO4, and concentrated