HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluoro-5-propoxyphenyl)boronic acid → HCID 59226511, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluoro-5-propoxyphenyl)boronic acid | HCID 16217464 | — |
| Reactant | 3-Amino-6-bromo-5-fluoropicolinic acid | HCID 72698879 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | HCID 59226511 | HCID 59226511 | 28% |
Reaction Steps
Method 1 was followed using 3-amino-6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-propoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 3-amino-5-fluoro-6-(2-fluoro-5-propoxyphenyl)picolinic acid in 28% yield. LC/MS=309.1 (M+H), Rt=1.00 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079889B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-9c00bfb5d136411b93cf8ec05da8d276 |
| Source note | uspto-grants-2015_07 |