HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenylboronic acid → Methyl 3-amino-5-fluoro-6-(2-fluorophenyl)picolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| Reactant | Methyl 3-amino-6-bromo-5-fluoropicolinate | HCID 72698878 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | Methyl 3-amino-5-fluoro-6-(2-fluorophenyl)picolinate | HCID 59226575 | 99% |
Reaction Steps
Method 1 was followed using methyl 3-amino-6-bromo-5-fluoropicolinate (1.0 equiv.) and 2-fluoro-phenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give methyl 3-amino-5-fluoro-6-(2-fluorophenyl)picolinate in >99% yield. LC/MS=265.0 (M+H), Rt=0.77 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079889B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-a95d6e9e35984f7790a1a55dc6292199 |
| Source note | uspto-grants-2015_07 |