HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorobenzeneboronic acid → 6-(3,4-Difluorophenyl)-5-fluoropicolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorobenzeneboronic acid | HCID 2734337 | — |
| Reactant | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 6-(3,4-Difluorophenyl)-5-fluoropicolinic acid | HCID 59226468 | 70% |
Reaction Steps
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 3,4-difluorophenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 6-(3,4-difluorophenyl)-5-fluoropicolinic acid in 70% yield. LC/MS=254.1 (M+H), Rt=0.81 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079889B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-48079fddfc334e16909d8886f6ec7f45 |
| Source note | uspto-grants-2015_07 |