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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1523488Generated: November 2, 2026

6-Bromopyridine-2-carboxylic acid → 6-(2-Fluorophenyl)pyridine-2-carboxylic acid

https://huagongshe.com/reaction/1523488

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromopyridine-2-carboxylic acidHCID 593919—
Reactant2-Fluorophenylboronic acidHCID 2734354—
CatalystHCID 178418807HCID 178418807—
Product6-(2-Fluorophenyl)pyridine-2-carboxylic acidHCID 2473013893%

Reaction Steps

Method 1 was followed using 6-bromopicolinic acid (1.0 equiv.) and 2-fluorophenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 6-(2-fluorophenyl)picolinic acid in 93% yield. LC/MS=218.0 (M+H), Rt=0.66 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09079889B2
Source datasetuspto-grants-2015_07
ORD IDord-ab4f494e4dc3470fad69816e8597595e
Source noteuspto-grants-2015_07