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HRID1523493

反应详情

EQUATION

反应方程式

HRID 1523493 的结构方程式

REACTANTS

反应物

2
结构：OB(O)c1ccccc1F
HCID2734354

(2-Fluorophenyl)boronato(2-)

C6H6BFO2

结构：O=C(O)c1nc(Br)ccc1F
HCID70700873

6-Bromo-3-fluoropyridine-2-carboxylic acid

C6H3BrFNO2

PRODUCTS

生成物

1
结构：O=C(O)c1nc(-c2ccccc2F)ccc1F
HCID46313903

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418807

未命名化合物

PROCEDURE

实验过程

Method 1 was followed using 6-bromo-3-fluoropicolinic acid (1.0 equiv.) and 2-fluorophenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 3-fluoro-6-(2-fluorophenyl)picolinic acid in 81% yield. LC/MS=236.1 (M+H), Rt=0.72 min.