化工社化工社 化学情報印刷レポート · 研究参考用
2-Fluoro-5-methoxyphenylboronic acid → 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| 反応物 | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 生成物 | 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid | HCID 59226605 | 86% |
反応手順
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-methoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 5-fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid in 86% yield. LC/MS=266.1 (M+H), Rt=0.79 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09079889B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-8e3910ea9a6e406eaee0c54c61867879 |
| 出典メモ | uspto-grants-2015_07 |