HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoro-4-methoxybenzeneboronic acid → 6-(2,6-Difluoro-4-methoxyphenyl)-3-fluoropicolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoro-4-methoxybenzeneboronic acid | HCID 16217424 | — |
| Reactant | 6-Bromo-3-fluoropyridine-2-carboxylic acid | HCID 70700873 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 6-(2,6-Difluoro-4-methoxyphenyl)-3-fluoropicolinic acid | HCID 59226556 | 9% |
Reaction Steps
Method 1 was followed using 6-bromo-3-fluoropicolinic acid (1.0 equiv.) and 2,6-difluoro-4-methoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 6-(2,6-difluoro-4-methoxyphenyl)-3-fluoropicolinic acid in 9% yield. LC/MS=284.0 (M+H), Rt=0.74 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079889B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-f6bc87538e0244238a5d865efaa1ad27 |
| Source note | uspto-grants-2015_07 |