HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-iodobenzoate → 1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-iodobenzoate | HCID 69273 | — |
| Reactant | 4-Hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 68682215 | — |
| Reactant | 1-Bromo-2-(4-chlorophenylsulfanyl)-5-(trifluoromethyl)benzene | HCID 68683413 | — |
| Product | 1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol | HCID 68683807 | — |
Reaction Steps
1-tert-Butoxycarbonyl-4-[2-(4-methoxycarbonyl-phenylsulfanyl)-phenyl]-piperidine-4-ol (intermediate for 4a) was prepared from 4-hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester, and 4-iodo-benzoic acid methyl ester by the palladium-catalysed coupling procedure described for 1-bromo-2-(4-chloro-phenylsulfanyl)-5-(trifluoromethyl)-benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732463B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e755c54ecda14b6e9ec408363ce84315 |
| Source note | uspto-grants-2010_06 |