反应详情

温度

120 °C

To a solution of 2-bromo-3-fluoro-6-methylpyridine (1.0 equiv.) in dioxane (0.2 M) was added 2,3,5-trifluorophenylboronic acid and Pd(dppf)Cl2-DCM (0.1 equiv.). Aqueous sodium carbonate (2M solution, 2.0 equiv.) was added and the reaction was heated in the microwave at 120° C. for 15 min. The solution was partitioned between ethyl acetate and sat. NaHCO3, the organic phase was washed with brine, dried with magnesium sulfate, filtered, and concentrated. The crude material was purified via silica gel column chromatography eluting with ethyl acetate and hexanes (1:3) to give 3-fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine in 87% yield. LC/MS=242.1 (M+H), Rt=0.98 min.

1. customThe solution was partitioned between ethyl acetate and sat. NaHCO3
2. washthe organic phase was washed with brine
3. dry with materialdried with magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude material was purified via silica gel column chromatography
7. washeluting with ethyl acetate and hexanes (1:3)