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HRID 1523527作成日：2026年10月26日

6-Bromo-5-fluoropicolinic Acid → (1R,2R,4R,6S)-4-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)-2-(tert-butoxycarbonylamino)-6-methylcyclohexyl acetate

https://huagongshe.com/reaction/1523527

反応式

関与物質

役割名称HCID仕込み量
反応物6-Bromo-5-fluoropicolinic AcidHCID 53401194—
反応物(1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-((tert-butoxycarbonyl)amino)-6-methylcyclohexyl acetateHCID 68555677—
溶媒Ethyl AcetateHCID 8857—
生成物(1R,2R,4R,6S)-4-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)-2-(tert-butoxycarbonylamino)-6-methylcyclohexyl acetateHCID 86639736—

反応手順

Following Method 9, (1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butoxycarbonylamino)-6-methylcyclohexyl acetate and 6-bromo-5-fluoropicolinic acid were coupled and following addition of EtOAc and washing with H2O, NaCl(sat.) and drying over MgSO4, (1R,2R,4R,6S)-4-(3-(6-bromo-5-fluoropicolinamido)pyridin-4-yl)-2-(tert-butoxycarbonylamino)-6-methylcyclohexyl acetate was obtained. LCMS (m/z): 567.2 (MH+), Rt=0.82 min.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09079889B2
出典データセットuspto-grants-2015_07
ORD IDord-432823c7688a4a09958421c1c70f5802
出典メモuspto-grants-2015_07