Methyl Ethyl Ketone → HCID 71272037, compound

Participants

Reaction Steps

(S)—N-benzyl-1-(oxiran-2-ylmethyl)methylamine (3.10 g, 19.06 mmol, 1.1 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in butanone (70 mL) respectively, and heated to reflux. Then lithium bromide (0.15 g, 1.74 mmol) was added, the mixture was reacted for 4 h, white solid was obtained by filtration (5.88 g, yield: 89.21%).

Provenance & Evidence