Water → HCID 86724914, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of [1,4′]Bipiperidinyl-4,1′-dicarboxylic acid diethyl ester (5.51 grams, 17.67 mmol), tetrahydrofuran (34 mL) and water (34 mL) cooled at 0° C., lithium hydroxide monohydrate (742.0 mg, 17.67 mml) was added. The reaction mixture was stirred at room temperature for 16 hours, diluted with Ethyl acetate. The two layers were separated, the aqueous layer was acidified with 2N hydrochloric acid to pH: 3-4 and the volatiles were removed under reduced pressure to obtain [1,4′]Bipiperidinyl-4,1′-dicarboxylic acid 1′-ethyl ester (5.0 grams).

Provenance & Evidence