Ether hydrochloride → HCID 90313628, compound

HRID 1523763Notes

Reaction equation

HRID 1523763 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([NH:17]C(=O)OC(C)(C)C)[CH2:12]1)(=[O:10])=[O:9].[ClH:25].CCOCC>C(Cl)Cl>[ClH:25].[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([NH2:17])[CH2:12]1)(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 90327718HCID 90327718, compound

Product 1

HCID 90313628HCID 90313628, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of racemic tert-butyl (1-((2-bromophenyl)sulfonyl)piperidin-3-yl)carbamate (82 mg, 0.20 mmol) in CH2Cl2 (5 mL) was treated with 2 N HCl/Et2O (1 mL, 2 mmol) and stirred 16 hours at rt. The reaction mixture was then concentrated to dryness to give the title compound in quantitative yield. The product was used without further purification.

Workup

  1. concentrationThe reaction mixture was then concentrated to dryness

Sources & evidence

ORD record
ord-54c9c520a67e48eaa5d5effe2df5f42d
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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