HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-((2-Bromo-5-(trifluoromethyl)phenyl)sulfonyl)piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 2-Bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2778613 | — |
| Product | 4-((2-Bromo-5-(trifluoromethyl)phenyl)sulfonyl)piperazin-2-one | HCID 90313243 | — |
Reaction Steps
The title compound was prepared in a manner similar to that described for Intermediate EU using piperazin-2-one and 2-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride. 1H NMR (400 MHz, CDCl3) δ 8.43-8.35 (d, J=2.3, 1H), 7.99-7.89 (d, J=8.2, 1H), 7.77-7.65 (dd, J=8.3, 2.3, 2H), 6.95 (s, 2H), 3.99 (s, 3H), 3.73-3.58 (t, J=5.3, 3H), 3.51-3.42 (m, 3H), 1.36-1.04 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079866B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-ea9f2db7931146e49993f7d322a6b731 |
| Source note | uspto-grants-2015_07 |