HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((2-Bromophenyl)sulfonyl)piperazine → 5-[3-Fluoro-2'-(piperazin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((2-Bromophenyl)sulfonyl)piperazine | HCID 2098016 | — |
| Reactant | 5-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)-pyrazin-2-amine | HCID 90312276 | — |
| Product | 5-[3-Fluoro-2'-(piperazin-1-ylsulfonyl)biphenyl-4-yl]pyrazin-2-amine | HCID 77844133 | — |
Reaction Steps
The title compound was prepared in a manner similar to that described in Example 448 using 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-pyrazin-2-amine and 1-((2-bromophenyl)sulfonyl)piperazine. MS (ESI): mass calcd. for C20H20FN5O2S, 413.13; m/z found, 414.1 [M+H]+. 1H NMR (400 MHz, CD3OD) δ 8.39 (m, 1H), 8.21-8.13 (m, 2H), 8.01-7.95 (m, 1H), 7.79-7.74 (m, 1H), 7.69-7.63 (m, 1H), 7.50-7.46 (m, 1H), 7.37-7.30 (m, 2H), 3.14-3.08 (m, 4H), 3.06-2.99 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079866B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-77168521f59f499da41605006e6b7d6c |
| Source note | uspto-grants-2015_07 |