2-Amino-3-bromopyridine → HCID 90313793, compound

HRID 1523931Notes

Reaction equation

HRID 1523931 reaction equation
Br[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:15]=[C:14](B2OC(C)(C)C(C)(C)O2)[CH:13]=[CH:12][C:11]=1[C:25]1[CH:26]=[N:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[NH2:8][C:3]1[C:2]([C:14]2[CH:13]=[CH:12][C:11]([C:25]3[CH:30]=[N:29][C:28]([NH2:31])=[N:27][CH:26]=3)=[C:10]([F:9])[CH:15]=2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 8177002-Amino-3-bromopyridineHCID 903131425-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidin-2-amine

Product 1

HCID 90313793HCID 90313793, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 88 using 3-bromopyridin-2-amine and 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidin-2-amine. MS (ESI): mass calcd. for C15H12FN5, 281.11; m/z found, 282.1 [M+H]+. 1H NMR (500 MHz, CD3OD) δ 8.64-8.54 (m, 1H), 8.00-7.89 (m, 1H), 7.74-7.64 (m, 1H), 7.46-7.36 (m, 1H), 7.09-7.03 (m, 1H).

Sources & evidence

ORD record
ord-c9f11623719941729163957910b68261
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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