2-bromo-7H-pyrrolo[2,3-d]pyrimidine → N-tert-Butyl-3'-fluoro-4'-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)biphenyl-2-sulfonamide

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 444 using N-(tert-butyl)-3′-fluoro-4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-2-sulfonamide and 2-bromo-7H-pyrrolo[2,3-d]pyrimidine. MS (ESI): mass calcd. for C22H21FN4O2S, 424.14; m/z found, 425.2 [M+H]+. 1H NMR (400 MHz, CD3OD) δ 9.31 (s, 1H), 8.82 (s, 1H), 8.15 (m, 1H), 7.90 (d, J=3.6, 1H), 7.68 (d, J=7.5, 1H), 7.63 (d, J=6.3, 1H), 7.50 (s, 1H), 7.42 (d, J=7.1, 1H), 7.02 (d, J=3.6, 1H), 6.66 (d, J=3.6, 1H), 1.12 (s, 9H).

Provenance & Evidence