1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene → 5-[2',3-Difluoro-4'-(trifluoromethoxy)biphenyl-4-yl]pyrazin-2-amine

Participants

Reaction Steps

The title compound was prepared using analogous conditions to those described in Example 1 utilizing 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazin-2-amine and 2-fluoro-4-(trifluoromethoxy)bromobenzene. MS (ESI): mass calcd. for C17H10F5N3O, 367.07; m/z found, 368.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ 8.40 (s, 1H), 8.03-7.96 (m, 2H), 7.78 (m, 1H), 7.56-7.49 (m, 3H), 7.37 (d, J=8.2, 1H), 6.75 (s, 2H).

Provenance & Evidence